What are the categories of Polyaluminum Chloride （PAC）

 Polyaluminum Chloride （PAC） Activator


An analytical standard for melatonin is standard melatonin( Standard). This publication contains research and analytical applications. The pineal gland releases melatonin receptors, which activates it. Sleeping-related meladipine has potent antioxidant and anti-inflammatory properties. A novel selective ATF-6 inhibitor, mitochondrialatonin, downregulates COX-2 and causes apoptosis in human hepatoma cells. Endoplasmic reticulum stress inhibits the palmitic acid-induced( HY-N0830) mouse granulosa cell apoptosis.


Standard melatonin


HY-131947


Antagonist DH97-7


With Ki values of 252 nM and 1100 nM for MT2 and MT1, respectively, DH97 is a potent melatonin receptor 2( MT2) antagonist.


DH97-7


HY-169382


Inhibitor of the melatonin-tamoxifen conjugate


A potent antagonist of ER( IC50=863 nM), the melatonin-tamoxifen conjugate( compound 16c) is known as the "metal-tamoxifen-compound conjugate "( compound 16c). In cells that express the hMT1 receptor, the melathifen-tamoxifen conjugate has the ability to bind to the MLT receptor( Ki=3.1 nM) and promote ERK activation and promoting -arrestin (EC50=914 nM) (EC50=98 nM). Compared to the common cell lines MCF-7, MDA-MB-231, and HT-1080, the IC50s of the melatonin-tamoxifen conjugate are 6.8M, 6.4%, and 1.7%, respectively.


Combination of melatonin and ammonia


HY-122136


Antagonist S26131 99.99%


S26131( compound 5) is a highly potent and selective MT1 melatonin ligand. The Ki values ​​for MT1 and MT2 are 0.5 and 112 nM, respectively. S26131 behaves as an MT1 and MT2 antagonist.


S26131


HY-B0075S


Melatonin-d4


Melatonin d4


Activator ≥99.0%


Melatonin-d4 is a deuterated form of melatonin. Melatonin is a hormone made by the pineal gland that activates the melatonin receptor. It has antioxidant and anti-inflammatory properties. Melatonin is a novel selective ATF-6 inhibitor that induces apoptosis in human hepatoma cells via COX-2 downregulation.


Melatonin-d4


HY-101358


8-M-PDOT Agonist 99.54%


8-M-PDOT( AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2 times more selective for MT2 than for MT1 receptors. 8-M-PDOT binds to human recombinant MT1 and MT2 receptors with pKi values ​​of 8.23 ​​and 8.95, respectively. 8-M-PDOT has anxiolytic activity.


8-M-PDOT


HY-101176


2-Iodomelatonin


2-Iodomelatonin


Agonist 99.04%


2-Iodomelatonin is a potent agonist of melatonin receptor 1( MT1) with a Ki of 28 pM and is more than 5-fold selective for MT1 over MT2.2-Iodomelatonin can be used to identify, characterize, and localize melatonin binding sites in brain and peripheral tissues.


2-Iodomelatonin


HY-14803


Tasimelteon


Tasimelteon



评论

发表评论

此博客中的热门博文

Barium Carbonate (BaCO₃): Properties, Production, Applications, and Safety

图片
  1. Introduction Barium Carbonate (BaCO₃) is an inorganic compound widely used in industries such as ceramics, glass, and chemicals. It is a white, odorless powder with limited solubility in water but soluble in acids. This article explores its properties, synthesis methods, applications, and safety measures in exhaustive detail. 2. Physical and Chemical Properties 2.1 Physical Properties Molecular Weight: 197.34 g/mol Appearance: White crystalline solid (rhombic or alpha form at room temperature) Density: 4.286 g/cm³ Melting Point: 811°C (decomposes to BaO + CO₂) Solubility: 0.002 g/100 mL (water, 20°C) Soluble in acids (e.g., HCl, HNO₃) 2.2 Chemical Properties Thermal Decomposition: BaCO3→ΔBaO+CO2↑ BaCO3ΔBaO+CO2↑ Reaction with Acids: BaCO3+2HCl→BaCl2+H2O+CO2↑ BaCO3+2HCl→BaCl2+H2O+CO2↑ Conversion to Barium Sulfate: BaCO3+H2SO4→BaSO4+H2O+CO2↑ BaCO3+H2SO4→BaSO4+H2O+CO2↑ 3. Production Methods 3.1 Carbonation Process Barium sulfide (BaS) solution is treated with CO₂: BaS+H2O+CO2→BaC...
阅读全文

What are the chemical components of Sophora flavescens

图片
Matrine  Sophora flavescens Chemical composition As early as the early 1930s, the Soviet Union began to study it abroad, and China began in 1972. The focus of research at home and abroad is on alkaloids. The alkaloids extracted, separated and identified from Sophora flavescens plants in China mainly include oxymatrine (C15H24N2O2), matrine (C15H24N2O), isomatrine (Iosmatrine, C15H24N2O), hydroxymatrine (sophor-anol), sophocarpine (C15H22N2O), N-oxysophocarpine (C15H22N2O2), sophoramine, sophoridine (Sophoridine, C15H24N2O), Aloperine, sparteine, N-methylcytisine, anagyrine, bap-iifoline, sophocarpine, d-matrine, d-isomatrine, d-oxymatrine, l-anagyrine, l-methyleytisine, l-baptifoline, kurarid-in, sophoranol (C15H24N2O2), sophoranhol N-oxide (C15H24N2O3), N-methylcytisine (C12H16N2O), and other alkaloids. Flavonoids: The flavonoids contained in Sophora flavescens are mostly dihydroflavones and dihydroflavonols, and there are also flavones, isoflavones, chalcones, etc. The flavonoids...
阅读全文